IKK 16

Product Name: IKK 16
CAS No.: 873225-46-8
Chemical Name: IKK 16
Synonyms: CS-1847;IKK Inhibitor;IKK 16 USP/EP/BP;IKK-16(free base);IKK Inhibitor VII;IKK16;IKK-16;IKK INHIBITOR VII;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase;[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone;Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-
CBNumber: CB92666638
Molecular Formula: C28H29N5OS
Formula Weight: 483.63
MOL File: 873225-46-8.mol

More

Less

IKK 16 Property

storage temp.: Store at -20°C
solubility: ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O
form: solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B207020
Product name: [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
Packaging: 10mg
Price: $185
Updated: 2021/12/16

ApexBio Technology

Product number: B1586
Product name: IKK-16(IKKInhibitorVII)
Packaging: 10mg
Price: $126
Updated: 2021/12/16

ChemScene

Product number: CS-1282
Product name: IKK16
Purity: 99.09%
Packaging: 10mg
Price: $174
Updated: 2021/12/16

ApexBio Technology

Product number: B1586
Product name: IKK-16(IKKInhibitorVII)
Packaging: 50mg
Price: $494
Updated: 2021/12/16

ChemScene

Product number: CS-1282
Product name: IKK16
Purity: 99.09%
Packaging: 50mg
Price: $714
Updated: 2021/12/16

More

Less

IKK 16 Chemical Properties,Usage,Production

Uses

IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.

Definition

ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].

target

IKK-2

References

[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.

IKK 16 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

IKK 16 Suppliers

Canada 1 China 74 United Kingdom 1 United States 13 Global 89

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

873225-46-8, IKK 16Related Search:

NA INK 128 (MLN0128) QNZ (EVP4593) MK-2206 2HCl TPCA-1 Trametinib IKK Inhibitor III, BMS-345541

IKK Inhibitor

[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone

IKK Inhibitor VII

Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-

1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine IKK-16 (IKK Inhibitor VII)

1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine

IKK16;IKK-16;IKK INHIBITOR VII

CS-1847

IKK-16(free base)

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

IKK 16 USP/EP/BP

Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase

873225-46-8

NF-kB

IκB/IKK

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds

Inhibitors